Abstract

1. 1. Various agonists induced sustained contractions of estrogen-dominated rat uterine smooth muscle in Ca-free salt solution containing 0.2mM EGTA after incubation of the muscle with 3 mM EGTA for 1 hr. 2. 2. The magnitudes of contraction varied with agonists. ( bradykinin > oxytocin≧vasopressin > -PGF 2α > angiotensin I > acetylcholine≧PGE 2≧5- hydroxytryptamine . 3. 3. Addition of 10 −4 Ca ion reduced the tension developed: Ca ion inhibited these contractions when they were sufficiently large (marked inhibition on bradykinin-, oxytocin-, and vasopressin-induced contractions; definite one on PGF 2α-induced contraction), as observed previously with oxytocin-induced contraction under the same conditions and named “Ca Reversal”.

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