Calcium Phosphate Functionalization and Applications in Dentistry

Abstract

The oral and maxillofacial hard tissues support the maxillofacial shape and serve as the foundation for functional activities. Defects in these tissues not only impair patients’ ability to perform their normal physiological functions but also have a significant negative impact on their psychological well-being. Moreover, these tissues have a limited capacity for self-healing, necessitating the use of artificial materials to repair defects. Calcium phosphate is a fine-grained inorganic biomineral found in vertebrate teeth and bones that has a comparable composition to human hard tissues. Calcium phosphate materials are biocompatible, bioactive, and osteogenic for hard tissue repair, despite drawbacks such as poor mechanical qualities, limiting their clinical efficacy and application. With the advancement of materials science and technology, numerous techniques have been developed to enhance the characteristics of calcium phosphate, and one of them is functionalization. Calcium phosphate can be functionally modified by changing its size, morphology, or composition through various preparation processes to achieve multifunctionality and improve physical and chemical properties, biocompatibility, and osteogenic potential. The purpose of this review is to provide new ideas for the treatment of oralmaxillofacial hard tissue defects and deficiencies by summarizing the functionalization strategies of calcium phosphate materials and their applications in dentistry.