Abstract
Seventy per cent of all kidney stones contain calcium oxalate. Urine is ordinarily supersaturated with respect to this salt and the question is why only some people form stones and why others only have crystalluria. In addition to particle retention in the upper urinary tract, lack of urinary inhibitors of crystallization may also be important. One of the best techniques to study the inhibitory activity of synthetic substances and of urine with respect to crystal growth is the constant composition approach of Sheehan and Nancollas1. Using this method the following problems have been investigated: (a) the influence of different seed crystals on the kinetics of crystal growth; (b) the inhibitory activity of different substances on crystal growth; and (c) the inhibitory potential of urine from recurrent calcium oxalate stone formers and from normal controls.
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