Abstract
A crucial step to achieve fertilization is oocyte activation, which occurs due to Ca2+ oscillations initiated by the sperm Phospholipase C (PLC). While the Intracytoplasmic Sperm injection (ICSI) has a high success rate, 2-3 % of couples have fertilization failure, with the major cause being failed oocyte activation. A recent meta-analysis revealed that Chemical Artificial Oocyte Activation (AOA) by means of a Ca2+-ionophore after ICSI improves fertilization, blastulation, implantation, pregnancy and live-birth rates in couples with poor fertilization rate (1).
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