Abstract
The discrete effects of serum calcium and endogenous parathyroid hormone (PTH) secretion upon gastric acidity were studied in patients with primary and secondary hyperparathyroidism and in others with upper gastrointestinal pathology. There was no correlation between PTH and basal acid secretion. An increase in acid secretion from the stomach associated with calcium infusion occurred in patients in all three groups and was related to changes in serum calcium concentration but not to PTH. These studies suggest that in man, endogenous parathyroid hormone has no direct stimulatory effect on gastric acid secretion but influences this indirectly by regulating calcium ion concentration.
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