Abstract
Tcb2 is a protein found in the cytoskeleton of the protozoan Tetrahymena thermophila. The calcium binding protein has been hypothesized to play roles involved with ciliary movement, pronuclear exchange, as well as cytoskeletal contractions triggered by Calcium binding. Solution NMR studies showed that although the C-domain of Tcb2 shares a common structure with other calcium binding proteins (two EF-hand paired motifs), the conformational change as a result of Calcium binding differs from Calmodulin.
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