Abstract
It is well known that the release of catecholamine from a perfused adrenal gland or adrenal medullary slices caused by acetylcholine or excess K+ is dependent on extracellular Ca++ (1, 2) and is associated with the influx of Ca++ into the cells (3). Therefore, the increased influx of Ca++ into the cells is thought to initiate catecholamine release from catechloamine storage granules in some way (4). On the other hand, we and others (5, 6) found that the release of catecholamine from isolated granules was greatly stimulated by ATP and Mg++. But the physiological significance of ATP.Mg++-stimulated catecholamine release is unknown. Accordingly, experiments were undertaken to see whether a low concentration of Ca++ might play a role in ATP.Mg++-stimulated catecholamine release from the granules.
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