Abstract
Observing the active role of lipids in response to chemical cues in artificial cell membranes could increase our understanding of directed cell transport phenomena in biological cells. Directed cell migration is essential in many biological processes including embryogenesis, wound healing, chronic inflammatory diseases, as well as cancer metastasis. Using biomimetic cell model systems makes it possible to use a minimal set of components for understanding directed cell movement and in-cell transport phenomena in regard to lipid sorting, formation of tubular protrusions and lipid movement. At present, we study directed lipid transport in artificial membranes by local biochemical gradient, calcium. We demonstrate that membrane tubulation and the flow of lipids in the membrane can be triggered and controlled by the chemical gradient applied along the lipid bilayer. This sheds light on interplay between membrane properties and chemical stimulation.
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