Abstract
The physiological and pharmacological properties of the Ca 2+ channel in outer hair cells (OHCs) freshly isolated from guinea pig cochlea were investigated using a whole-cell patch-clamp technique. The Ca 2+ current ( I Ca) was activated from a membrane potential of −20 mV and reached peak value around +20 mV in external solution containing 20 mM Ca 2+ at a holding potential of −70 mV. The peak amplitude of I Ca increased in a hyperbolic manner with increasing extracellular Ca 2+ concentration. The ion selectively was Ba 2+ > > Ca 2+ ⩾Sr 2+. It was concluded that the Ca 2+ channel in OHCs of guinea pig is of the L-type.
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