Calcium Channel Antagonists and Gingival Hyperplasia

Abstract

Letters15 October 1994Calcium Channel Antagonists and Gingival HyperplasiaRuth Steele, PharmD, Arthur A. Schuna, MD, and Ronald Schreiber, MDRuth Steele, PharmDSearch for more papers by this author, Arthur A. Schuna, MDSearch for more papers by this author, and Ronald Schreiber, MDSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-121-8-199410150-00021 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail IN RESPONSE:Drs. Mathis and Scheetz raise some interesting questions regarding the dosage form of calcium antagonist and gingival hyperplasia. Because most of our patients received sustained-release preparations of calcium antagonists, we could not do a subgroup analysis with adequate numbers of patients receiving prompt-release dosage forms to do statistical comparisons. We did not assess blood levels or compliance in this prevalence survey; however, previous reports found no relation between the dosage of the calcium antagonist and the development of gingival hyperplasia [1, 2]. We found no statistical differences in age between patients with and without hyperplasia. Our patient population ...REFERENCE1. Barclay S, Thomason JM, Idle JR, Seymour RA. The incidence and severity of nifedipine-induced gingival overgrowth. J Clin Periodontol. 1992; 19:311-4. Google Scholar2. Veraldi S, Piferi M, Marini D. Gingival hyperplasia following nifedipine therapy (Letter). Clin Exp Dermatol. 1989; 14:93. Google Scholar3. Hancock RH, Swan RH. Nifedipine-induced gingival overgrowth: report of a case treated by controlling plaque. J Clin Periodontol. 1992; 19:12-4. Google Scholar4. Modeer T, Dahllof G. Development of phenytoin-induced gingival overgrowth in non-institutionalized epileptic children subjected to different plaque control programs. Acta Odontol Scand. 1987; 45:81-5. Google Scholar5. Pihlstrom BL, Carlson JF, Smith QT, Bastien SA, Keenan KM. Prevention of phenytoin associated gingival enlargement—a 15-month longitudinal study. J Periodontol. 1980; 51:311-7. Google Scholar Author, Article, and Disclosure InformationAffiliations: PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 15 October 1994Volume 121, Issue 8Page: 624-625KeywordsCalciumCalcium antagonist therapyCalcium channel blockerForecastingGeriatricsHemorrhageHygieneInflammationPeriodontal diseasesRacial and ethnic issues ePublished: 15 August 2000 Issue Published: 15 October 1994 Copyright & PermissionsCopyright © 1994 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...