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Abstract
Why are cardiologists so interested in “calcium antagonists?” Firstly, active coronary vasomotor changes are now recognized to play an important role in certain anginal syndromes. Coronary spasm superimposed on atherosclerotic coronary artery disease is probably the most important contributing factor to angina at rest. Secondly, knowledge regarding the mechanism of contraction of vascular smooth muscle is rapidly advancing and the important role played by transmembrane calcium flux in this process is being defined.
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