Abstract
It is commonly accepted that hypercalcemia and functional hypoparathyroidism are present at birth in term infants. However whether this is a constant finding or is subjected to seasonal variations, as recently shown for 25 hydroxycholecalciferol cord values, has not been studied. Determinations of Ca, P, iPTH and iCT were carried out in February in cord sera from 28 normal term infants (gestational age : 38 to 41 weeks). Mean ± SD serum concentrations were : Ca : 9.21 ±1.34 mg/dl ; P : 4.6 ± 0.99 mg/dl. Serum iPTH levels were undetectable (<25 μlEq/ml) in 8 cases, normal in 17 cases (mean : 43 μlEq/ml ; range : 28 to 95) and above the normal range (>100 μlEq/ml) in one case. Serum iCT levels were not detectable (<150 pg/ml) in 48% of the determinations and above the normal values in children and adults (non detectable) in 12/23 determinations (mean : 230 pg/ml ; range : 160 to 430). There was no correlation between serum Ca or P levels and respectively serum iPTH or iCT levels. Conclusion : In cord sera from term infants born in February, hypercalcemia does not appear as usual as commonly said. Farthermore there is good evidence for a parathyroid activity and for hypercalcitoninemia in many cases. Whether these results are effectively related to seasonal variations would disserve further studies.
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