Calcium ATPase signaling: A must include mechanism in the Radar of therapeutics development against Tuberculosis.

Abstract

An article presented by Peterson and Verkhratsky in 2016 explore the linkage of calcium and ATP for a themed issue of "Evolution brings Ca2+ and ATP together to control life and death". The article impacted due to several findings of their cooperative functioning such as the formulation of ATP necessitates a small concentration of cytosolic Ca2+ , and therefore leads these two molecules together. The low cytosolic Ca2+ concentration is a primary advantage of its function like a universal secondary messenger. The present article also explores the essential facts about Ca2+ -ATP signaling in response to tuberculosis (TB). TB is still a major causal mortality of an important fraction of worldwide population and therefore we require an urgent regimen for its treatment. The new strategies that cover all forms of the disease MDR, XDR and TDR are necessity to overcome the disease pattern and its outcomes. Ionophores and channels mediated transportation of Ca2+ that leads to elevation of intra cellular Ca2+ concentration provide an important clue to divert the focus towards this signaling mechanism. P2×7 pathway is an enormous Ca2+ signaling pathway that incorporated Ca2+ influx and Potassium efflux upon activation by ATP molecule. After this activation, immune components like 1L-12 and IL-6 release and generate a protective response against pathogen. This review highlights importance of togetherness of Ca2+ and ATP signaling with new and more emphasize view of Ca2+ regulation. This article is protected by copyright. All rights reserved.