Abstract
In this work blends based on calcium aluminate cement (CAC) containing bioactive glass (BG) (5, 7.5 and 10 wt%) and strontium oxide (1 wt%) were produced aiming improve their bioactivity and the capacity to stimulate the bone regeneration. In the first part, the blends containing only BG were characterized as theoretical density, microhardness, uniaxial cold crush strength after SBF and apparent porosity and pore size distribution before and after SBF treatment. In the second part, bioactivity and cell culture tests were also conducted in the blends containing BG and strontium oxide. The addition of 7.5 wt% of BG in homogeneous calcium aluminate cement (CH) improved its mechanical properties as microhardness and uniaxial cold crushing strength. The blends were more bioactive due to the presence of a highly soluble amorphous phase as confirmed by means of SEM/EDX mainly for 7.5 wt% BG without and with Sr from 1 day in SBF. FTIR analyses indicated the formation the apatite-like phase by means of increase of intensity of the PO43- peaks after SBF treatment. All blends allowed the development of the osteoblastic phenotype and the formation of mineralized matrix increased due to the inclusion of BG and Sr promoting the osteogenesis process.
Highlights
Disorders related to bone tissue can lead to bone loss, and often caused by inflammatory diseases, trauma, tumors or degenerative diseases
The present study focused on assessing the influence of bioactive glass (BG) addition on some properties of calcium aluminate cement
The present study evaluates the influence of BG addition on some properties of homogeneous calcium aluminate cement (CH)
Summary
Disorders related to bone tissue can lead to bone loss, and often caused by inflammatory diseases, trauma, tumors or degenerative diseases. Among the biomaterials reported in scientific researches as a potential substitute in bone repairing, calcium aluminate cement (CAC) has been heightened for its physical, mechanical, and biocompatibility properties[5,6]. This material presents unique characteristics of curing, hardening, related microstructure[2,6,7], and thermal expansion coefficient which are very similar to that of human bone[8,9]. It has the ability to chemically bond to bone tissues, forming a layer of apathy on its surface when exposed to physiological fluids, exhibiting excellent bioactivity, which can be explained by the similarity between the composition and the structure of the bioactive materials with the mineral phase of the bone[14]
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