Abstract
In free-standing hair bundle, depolarization to +80 mV evoked a stable outward current and repolarization to −80 mV evoked a transient inward current attributable to the opening of mechano-electric transducer channels. The study investigated the Ca2+ dependence of this transducer-like membrane current in isolated inner hair cells of guinea-pig cochlea. The amplitude of outward currents increased and the rate of inward current decay, corresponding to adaptation kinetics, decreasing as the extracellular Ca2+ concentrations lessened, whereas the amplitude of outward current decreased and an adaptation accelerated as the extracellular Ca2+ elevated. Treatment with the cAMP agonist, 8-bromo-cAMP, induced an effect similar to that caused by elevating the extracellular Ca2+.
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