Calcitonin receptor‐like receptor (CLR), receptor activity‐modifying protein 1 (RAMP1), and calcitonin gene‐related peptide (CGRP) immunoreactivity in the rat trigeminovascular system: Differences between peripheral and central CGRP receptor distribution

Abstract

AbstractCGRP meets its receptor in the rat dura mater. The CGRP receptor protein CLR (green) is expressed in smooth muscle cells (blue, SMA) in the media of meningeal arteries (left) but not in veins (right upper half). CLR is also found in trigeminal nerve bundles and mononuclear cells adjacent to the arteries. CGRP‐receptor components are however not colocalized with axonal CGRP (red) in the dura, but expressed in Schwann cells (not visible at this magnification). J. Comp. Neurol. 507:1277‐1299, 2008. © 2008 Wiley‐Liss, Inc.