Abstract
The effects of human α-calcitonin gene-related peptide (α-CGRP), β-CGRP, and vasoactive intestinal polypeptide (VIP) on left gastric (LGA) and superior mesenteric arterial (SMA) blood flow, heart rate and systemic arterial blood pressure were investigated in 6 conscious beagle dogs. Both intravenous injections of α-CGRP and β-CGRP (5–200 pmol/kg) and infusion of α-CGRP (25–100 pmol/kg per h) induced a dose-related increase in SMA flow and a dose-related decrease in its resistance. At lower doses, α-CGRP was more potent than β-CGRP, but their maximal responses were the same. α-CGRP and β-CGRP had little effect on LGA flow. However, α-CGRP at 200 pmol/kg, but not β-CGRP, stimulated gastroduodenal contractions that were associated with a phasic increase of LGA flow. Atropine inhibited gastric, but not duodenal, motor and circulatory responses to α-CGRP. Tachycardia and hypotension induced by β-CGRP were significantly less than those by α-CGRP. VIP, on the other hand, increased mainly LGA flow. These results suggest that blood vessels of the small intestine of dogs are more sensitive to CGRP than those of the stomach, while the sensitivity to VIP is reversed.
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