Abstract
A 51-year-old woman with a diagnosis of scleroderma-polymyositis overlap syndrome presented to our rheumatology department with widespread subcutaneous skin lesions. On examination, widespread subcutaneous calcification was noted, affecting the elbows, shoulders, hips, knees, buttocks, and ankles. She was positive for anti-nuclear antibodies, anti-La, anti-Ro, and anti-PM-SCL-75 antibodies. Tests for parathyroid hormone, renal function, calcium, and vitamin D were normal. Extensive investigation including PET-CT and upper gastrointestinal endoscopy, and chest, abdomen, and pelvis CT excluded malignancy.
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