Abstract
Calcinosis cutis is defined as deposition of insoluble calcium salts in the skin and subcutaneous tissues. It can occur in multiple disorders but it is commonly seen in systemic sclerosis (SSc) especially in the limited type. It is frequently a late finding, but can develop at any point during the disease process and the severity varies from single small lesions typically in the hands to generalized calcinosis also known as calcinosis universalis. The pathogenesis is not well understood but theories include calcium and phosphate microenvironment imbalance, inflammatory causes, and chronic/recurrent ischemia. Calcinosis cutis is a common cause of morbidity in SSc patients and currently there is no treatment consensus although multiple therapies have been attempted with varying degrees of success.
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