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Abstract
Calcineurin inhibitors can block calcineurin signaling pathway,thereby suppress T-cell activation.In the past,it was used as an immunosuppressant for immunoregulation after organ transplantation.Recent studies have found that they are also effective for the treatment of some inflammatory skin diseases such as psoriasis and atopic dermatitis.Their efficacy is close to that of corticosteroids but they do not induce skin atrophy.Tacrolimus ointment and pimecrolimus cream are expected to be an alternative to topical corticosteroids in the treatment of psoriasis.This review presents the clinical efficacy,mechanism of action and side effects of several calcineurin inhibitors in the treatment of psoriasis. Key words: Psoriasis; Calcineurin inhibitors; Therapy
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