Abstract
Calcifying odontogenic cyst (COC) is a rare odontogenic lesion derived from the remaining odontogenic epithelium of the jaws. Radiographically, it is a destructive lesion, and the cortical plates of bone are thin and expanded. Here, we report a case series of 3 patients diagnosed with central COC. Microscopic and immunohistochemical analyses were performed. Two cases occurred in women, with mean age of 34.3 years. All cases occurred in the maxilla, without symptomatology, presenting as an expansive tumor-like mass. The differential diagnosis included residual cyst, ameloblastoma, Pindborg tumor, adenomatoid odontogenic tumor, odontogenic fibroma, developing odontoma, and fibro-osseous lesion. Immunohistochemistry supports an odontogenic origin with low proliferative index. COC is an uncommon lesion that should be considered by clinicians in the differential diagnosis of odontogenic cysts or tumors, especially when mineralized deposits are detected on imaginologic exams. Intraosseous COC is mainly treated by enucleation, with rare or low rate of recurrence.
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