Calcifying Epithelial Odontogenic Tumor: A Case Series Spanning 25 years

Abstract

The calcifying epithelial odontogenic tumor (CEOT), also known as the Pindborg tumor, is a rare benign neoplasm which makes up less than 1% of all odontogenic tumors. The purpose of this study is to describe a series of cases of CEOT spanning 25 years. METHODS: With IRB approval, all cases diagnosed as CEOT between 1994 and 2019 were retrieved from the archives of the UF Oral Pathology Biopsy Service. RESULTS: A total of 22 cases were included in the study. Patient age ranged from 8 years to 70 years with an average of 40 years. Females were affected slightly more often (55%, n=12) than males (45%, n=10). The mandible was a more common location (55%, n=12) than the maxilla (45%, n=10) by a small margin. A clinical impression was provided by the clinician in 17 cases, of which the most common (53%, n=9) was that of a cystic lesion (including dentigerous/follicular cyst, periapical/inflammatory cyst, lateral periodontal cyst and odontogenic keratocyst). Radiographs were available for 7 cases and the most common radiographic presentation was a unilocular mixed radiolucent/radiopaque lesion (43%, n=3). Lesion du- ration was provided in 9 cases and the range was from 3 months to 10 years. The histologic diagnosis of CEOT was made for all cases. One case was believed to represent a recurrent tumor. Also included were the variants "incip- ient CEOT" (8%, n=2) and "peripheral CEOT" (8%, n=2). One case exhibited features of adenomatoid odontogenic tumor in addition to CEOT. Congo red staining for amyloid was performed in 14 cases, all of which were positive. CONCLUSION: CEOT is an uncommon tumor with a variable presentation and affects patients across a wide age range. Although most cases are intraosseous, the peripheral counterpart is occasionally encountered.