Abstract
Purpose: Osteoarthritis (OA) and chondrocalcinosis (CC) are common arthropathies associated with the accumulation of calcium-containing crystals in the cartilage and synovial membrane. Basic calcium phosphate (BCP) crystals are present in OA, whereas calcium phosphate dehydrate (CPPD) crystals are a characteristic of CC. Further, BCP crystals have been linked to Wnt signaling and hypertrophic differentiation of chondrocytes, whereas CPPD crystals may be responsible for chondrocyte senescence. Despite their association with different types of calcium crystals, OA and CC share similar phenotypes including a progressive degeneration and calcification of articular cartilage.
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