CAIDE dementia risk score and cognitive correlates among Filipinos with mild cognitive impairment

Abstract

AbstractBackgroundThe Cardiovascular Risk Factors, Aging and Dementia (CAIDE) dementia risk score is a validated tool predicting the risk of dementia.1,2 It includes age, sex, education, blood pressure, cholesterol, body mass index (BMI), and physical inactivity, with higher scores indicating increased risk of subsequent dementia.1,2 Mild Cognitive Impairment (MCI) is a The objective is to compare the cognitive profiles of Mild Cognitive Impairment (MCI) participants with significant modifiable risk factors (CAIDE > 6) in a Filipino cohort.MethodA total of 60 participants with MCI from the Filipino Multicomponent Intervention to Maintain Cognitive Performance among High Risks Population (FINOMAIN) study were included. Data on age, sex, educational level, blood pressure, cholesterol, body mass index (BMI), and physical activity were obtained. Mini Mental Status Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores were obtained. Participants were administered the Mini‐Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), and Alzheimer’s Disease Assessment Scale Cognitive Subscale (ADAS‐Cog).ResultForty‐four participants (73%) have significant modifiable risk factors (CAIDE > 6). Compared to participants without significant risk factors, participants with significant modifiable risk factors (CAIDE > 6) have more impaired cognition with lower MoCA scores (16 + 4 vs 19 + 3, p=0.02). MMSE was noted to be lower (25 + 3 vs 27 + 2, p=0.06); and ADAS‐Cog scores higher (13.6 + 6 vs 11.8 + 5, p=0.2), however, it was not significant.ConclusionThis study shows that MCI participants with significant modifiable risk factors (CAIDE > 6) have more cognitive impairment suggesting the utility of CAIDE in the community to screen individuals at risk for dementia. Findings support the need to address modifiable risk factors to prevent cognitive deterioration. Further trials that investigate the effects of multi‐domain intervention and treatment for risk factors in improving cognition, delaying cognitive deterioration and dementia conversion.