Abstract
loop regulating CagA phosphorylation status and activity [18]. The second mechanism of host protein dephosphorylation was defined by the ability of activated CagAp-Tyr to bind to the SH2domain of Shp-2 tyrosine phosphatase [19], which triggered the dephosphorylation of focal adhesion kinase (FAK)and as a consequence of FAK substrates like Paxillin [20]. In gastric epithelial cells reduced FAK activity leads to a reduction of focal adhesion sites and contributes to cell detachment and increased cell motility.
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