CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion

Abstract

Editor's Note: In Writ e Click this week, in reference to “CAG repeat expansion in Huntington disease determines age at onset in a fully dominant fashion” by Lee et al., Drs. Aziz and Roos question the study's use of motor onset as the only marker for disease onset. The authors clarify the rationale behind their methodology. Drs. Meng, Zhang, and Kao ask authors Klein et al. about the differences between the neuronal connectivity networks of the STN and VIM in reference to their recent study on deep brain stimulation. Authors Klein et al. summarize recent studies into the circuitry. Megan Alcauskas, MD, and Robert C. Griggs, MD . # {#article-title-2} We read with interest the article by Lee et al.1 concerning the potential effect of the CAG repeat size in the normal HTT allele on age at motor onset in Huntington disease (HD). Although the authors have done an excellent job in analyzing data on an …