Abstract
Gastric, submucosal administration of caffeine induced hydrochloric acid secretion in the rat. Evidence obtained from bilaterally vagotomized rats treated with parasympatholytic agents indicated that caffeine stimulation is mediated via intramural myenteric plexuses within the stomach. It is concluded that the primary mode of action of caffeine in ulcerogenesis in the rat is augmentation of gastric secretion. The spontaneous secretion of gastric acid in fasting rats was confirmed.
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