Abstract
Background: Caffeine improves exercise performance for some people, but not all. The reason for this variability is unknown. Differences in caffeine sensitivity have been explained by variation in a single nucleotide polymorphism in ADORA2A (rs5751876), a gene that codes for the adenosine A2A receptor. Carriers of the C allele (CT/CC) consume more caffeine and are less sensitive to caffeine than T allele homozygotes (TT). The study aim was to determine if the polymorphism in ADORA2A influences the effect of the adenosine antagonist caffeine on total work performed during a cycling time trial. Methods: Women with high self-reported caffeine sensitivity and low daily caffeine consumption participated in a randomized, double-blinded, crossover experiment. On visit 1, participants performed a cycling \documentclass{aastex}\usepackage{amsbsy}\usepackage{amsfonts}\usepackage{amssymb}\usepackage{bm}\usepackage{mathrsfs}\usepackage{pifont}\usepackage{stmaryrd}\usepackage{textcomp}\usepackage{portland, xspace}\use...
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