Caffeine for Apnea of Prematurity

Abstract

Caffeine is one of the most commonly prescribed drugs among premature infants. It is a potent respiratory stimulant indicated primarily to reduce the incidence of episodes of apnea associated with an immature central nervous system. It is also used frequently in these infants to facilitate weaning from mechanical ventilation. Despite the widespread use of caffeine for these indications, the evidence to support its use is based on the results of a few relatively small and short-term studies.1 Information is lacking on possible long-term effects of prolonged administration of caffeine on the development of the brain and other organs. In this . . .