Abstract
Café Au Lait Spots as a Marker of Neuropaediatric Diseases
Highlights
The Café au lait spots (CALS) are shown in the normal population without pathological significance, they could be criteria for some neurologic syndromes
The prevalence of CALS was significantly higher among the patients admitted because of neurologic problems excluding syndromes or illnesses associated to them
The high prevalence of this type of cutaneous pigmentary abnormalities that appear among patients with mutations in mTOR genes, suggests that the pathophysiological mechanism that mediates their appearance uses the same systems by which the proliferation of other cell lines leads to the formation of neoplastic lesions [4,5,6,7], especially in the early stages of life in
Summary
The Café au lait spots (CALS) are shown in the normal population without pathological significance, they could be criteria for some neurologic syndromes. Within the cutaneous macules that appear as dyschromia, the hyper pigmented ones, especially the so-called café au lait spots (CALS) are the most recognizable by their tone and shape and their less variability with respect to other types of dyschromia. This has allowed them to be associated with a series of clinical syndromes for which the diagnosis becomes a major criterion, such as Neurofibromatosis type 1 [4,5].
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