Abstract
Vibrio vulnificus is a human opportunistic pathogen which causes fatal septicemia and necrotic wound infection, resulting in a high mortality (over 50%). Caenorhabditis elegans has been studied as a model experimental host for V. vulnificus infection. V. vulnificus was shown to kill C. elegans effectively on different growth media and culture conditions. A marked reduction was observed in the life spans of worms when they were fed on V. vulnificus rather than on the ordinary laboratory food source, Escherichia coli OP50. The intestines of the C. elegans fed on V. vulnificus were grossly distended. In the C. elegans infection model, a V. vulnificus global virulence regulator CRP mutant and an exotoxin mutant exhibited significantly extended host killing duration. Here, we have shown that the virulence factors essential to mammalian V. vulnificus infections also play important roles in the killing of C. elegans, and thereby suggest that C. elegans is a favorable model for host–parasite interaction.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
