Abstract
Exposure to cadmium results in the production of renal metallothionein (MT) (1–5). In the kidney, MT will bind zinc as well as cadmium (1,2). Studies of renal MT obtained from normal horses, with a comparably high concentration of cadmium in their kidneys, have shown that the relative content of zinc in MT decreases with increasing cadmium concentration in the kidney (4). In rats it has been demonstrated that renal MT may also bind copper (6). It is believed that toxic effects caused by cadmium in the kidney will emerge when the tubular cells are unable to produce enough MT to sequester all cadmium ions (2,7).KeywordsUrinary ExcretionRelative ContentKidney CortexKarolinska InstituteRabbit KidneyThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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