Abstract
Cadmium is an environmental hazard that causes cell damage. Cytotoxicity and cell death has been clearly demonstrated in liver and kidney. However, the specific toxic effect at the molecular level remains to be elucidated. In this study we have used Chinese Hamsters Ovary Cells (CHOs) to investigate the genetic and molecular mechanisms of cadmium toxicity. Cell viability assays, gene expression of metal binding proteins and non‐coding RNAs analysis have been done by Reverse Transcription Quantitative Polymerase Chain Reaction (RTqPCR). Exposition of CHOs to μM concentrations of cadmium, showed a correlation with cell death, overexpression of metallothioneins, and down‐regulation and up‐regulation and small non‐coding RNAs. These results suggest a role of small non‐coding RNAs in cadmium toxic effects in animal cells. This work was supported by US Department of Education, Award # PO31C110181.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
