Abstract
The present study was designed to investigate the effects of Cd exposure on locomotor behaviour in F1 mice whose dams were exposed to low dose cadmium for a short duration during the lactation period and whether quercetin could modulate the effects. The locomotor behaviour and musculoskeletal activity were tested using photoactomter and rota rod test respectively. We observed that at the given dose of Cd (1.2mg/kg) for a short duration, the muscle coordination on rota rod showed significant improvement as compared to the control group. Cotreatment of Cd with quercetin (100mg/kg) further enhanced the rota rod activity. Similarly the spontaneous motor activity as tested on the photoactometer also exhibited improvement in Cd treated group though this change was not statistically significant. However, Cd when cotreated with quercetin (50 mg/kg) showed significant enhancement in photoactometer activity compared to control. Quercetin administered alone (dose 25 mg/kg) also demonstrated significantly improved rota rod and photoactometer activity as compared to control. Thus cadmium exposure to dams at dose (1.2mg/kg) during lactation may
Highlights
Cadmium is one of the most toxic environmental pollutants which have increased in distribution due to industrial activities [1]
The present study was designed to investigate the effects of Cd exposure in F1 mice whose dams were exposed to low dose cadmium for a short duration during the lactation period
Quercetin was administered in doses of 25 mg/kg/day, 50 mg/kg/day and 100 mg/kg/day, i.p
Summary
Cadmium is one of the most toxic environmental pollutants which have increased in distribution due to industrial activities [1]. Itai-Itai disease is the most severe form of chronic Cd poisoning is caused by prolonged Cd exposure and is mainly characterized by osteomalacia [3,4]. This disease was initially described in post-menopausal Japanese women who were chronically exposed to cadmium in Japan. They suffered from defective gait, leg pain and bone deformities [5]. The effects of cadmium exposure on locomotor activity in the reproductive age-group and on their subsequent off-springs have not been much explored. The present study was designed to investigate the effects of Cd exposure in F1 mice whose dams were exposed to low dose cadmium for a short duration during the lactation period
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
