Abstract
One-pot synthesis of benzimidazoles has been carried out using ortho-phenylenediamine and aldehydes. The condensation reaction smoothly took place in the presence of a mild Lewis acid cadmium chloride. All the reactions were carried out in acetonitrile at 80°C to 85°C.
Highlights
Molecules having benzimidazole as a basic structural unit are known to exhibit a wide range of biological properties [1-3]
Several efforts have been developed for the synthesis of benzimidazole derivatives
One of the most common methods for the preparation of benzimidazole derivatives involves the condensation of arylenediamines and carbonyl compounds such as aldehydes and acid derivatives [10-12]
Summary
Molecules having benzimidazole as a basic structural unit are known to exhibit a wide range of biological properties [1-3]. The synthesis of benzimodazoles and its derivatives occupies pivotal position in the field of organic synthesis In this contest, several efforts have been developed for the synthesis of benzimidazole derivatives. The other way involves the oxidative cyclodehydrogenation of Schiff bases, which is generated from phenylene diamine and aldehyde in the presence of various oxidative and catalytic reagents. This is the most popular approach in general for the synthesis of benzimidazole derivatives. Several catalysts such as metal halides and metaloxychlorides [25-30], metal oxides, PTSA, metal Many of these methods suffer from drawbacks such as drastic reaction conditions [14], low yields [16], tedious workup procedures [22] and co-occurrence of several side reactions [20]. The introduction of an efficient and mild method is still needed to overcome these limitations
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
