Abstract

OBJECTIVE: Actin dynamics affects cell cycle progression, cell junction function, spermiogenesis and spermiation. Actin immunoreactivity is low in testis of infertile men with varicocele. Varicocele actin loss may lead to sloughing of germ cells, increased apoptosis, and abnormal sperm head shape. Testes cadmium (Cd) is elevated in infertile men with varicoceles. Athough Cd can directly disassemble and degrade actin, it may also reduce actin by altering gene expression. In this study, we asked if Cd changed actin-related gene expression in mammalian testes.

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