CADD Approaches and Antiviral Drug Discovery

Abstract

The virus causes an infection that every year threatens the health of people all over the world and costs a lot of money. Even though there are now new types of viruses, antiviral drugs are still the best way to treat them. Computer-aided drug design (CADD) offers the chance to make new drugs quickly and effectively, which is different from the problems that come up in traditional research on small-molecule therapies. This chapter talks about the basics of CADD, talks about the viral proteins that are important for the virus to replicate and could be used as therapeutic targets for antiviral drugs, gives examples of how CADD has been used to screen target proteins, and talks about the general CADD procedures for both structure-based drug design and ligand-based drug design, with a focus on the strategies and targets that are commonly studied.