Abstract
We read with interest the recent study by Yamamoto et al (1) in which the authors demonstrated the specificity of anti-NOTCH3 ectodomain antibodies in CADASIL patients and confirmed the predominant localization of NOTCH3 ectodomain in granular osmiophilic material (GOM) deposits. The authors also documented widespread accumulation and distribution of NOTCH3 ectodomain in the meninges and cerebral microcirculation, particularly in capillaries. In particular, Figure 7B shows a perivascular cell that …
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