Abstract
HighlightsCaCO3-assisted double emulsion method was developed to prepare pH-responsive nanoparticles enabling effective encapsulation of diverse molecules.The introducing of CaCO3 could enable deep intratumoral penetration of therapeutic agents and effective neutralization of acidic tumor pH to favor the reverse of immunosuppressive tumor microenvironment (TME).The reverse of immunosuppressive TME ascribing to NLG919-mediated IDO1 inhibition and CaCO3-mediated neutralization of acidic TME could collectively contribute to augmented chemo-immunotherapy of cancer.
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