Cabergoline plus Lanreotide for Ectopic Cushing's Syndrome

Abstract

To the Editor: The ectopic corticotropin syndrome, a rare cause of chronic endogenous hypercortisolism, accounts for 15 to 20 percent of corticotropin-dependent Cushing's syndrome and 5 to 10 percent of cases of Cushing's syndrome overall.1,2 This syndrome is often associated with corticotropin-secreting lung carcinoid tumors. The treatment of choice in cases in which the syndrome is associated with lung carcinoid is surgery, but the success rate of surgery is limited owing to the persistence of tumor remnants,3 which frequently necessitate palliative medical treatment to inhibit adrenal cortisol secretion. Somatostatin analogues have been observed to be effective in controlling carcinoid . . .