Abstract
The Nogo gene was putatively implicated in schizophrenia based on gene expression and genetic association data. In this study, we attempt to replicate the possible association of the CAA insertion and a nearby TATC deletion with schizophrenia in 204 complete and incomplete triads and in a sample of 462 unrelated cases and 153 controls, all of Caucasian origin. Our genotyping results indicated that neither the trinucleotide insertion polymorphism (CAA ins; 43.4% vs. 41.8%, p>0.5) nor the polymorphism-TATC deletion (TATC del; 49.8% vs. 49.3%, p>0.1) allele frequency is significantly different in patients compared to controls. The homozygous CAA ins frequency is not significantly different between patients and controls either (18.0% vs. 15.0%, χ 2=0.985, p>0.1). Furthermore, neither CAA ins/TATC del individually, nor the haplotype carrying both CAA ins and TATC del is preferentially transmitted to affected offspring.
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