Abstract
Continuous tetanic stimulation of the nerve caused slow rises in intracellular Ca2+ in motor nerve terminals and the frequency of miniature end-plate potential (MEPP) over a few minutes in frog skeletal muscles. These rises were dependent in amplitude and rise time on extracellular Ca2+ and stimulation frequency and blocked by blockers of ryanodine receptors, ryanodine, and TMB-8, but not by CN-, indicating the activation of Ca2+-induced Ca2+ release. Perturbation of the slow transient rises in intracellular Ca2+ in nerve terminals and MEPP frequency by short ( 1 min) pauses in tetanus revealed the unique characteristics of priming, activation, inactivation, deinactivation, and depriming processes of the Ca2+-induced Ca2+ release mechanism at frog motor nerve terminals.
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