Abstract
Ca2+-Dependent and Ca2+-Independent ATP Release in Astrocytes.
Highlights
Like neurons, astrocytes are abundant in the central nervous system
ATP was thought to be released through specific channels, such as connexin/pannexin hemichannels, “maxi-anion” channels, and P2X7 receptor channels (Figure 1A, Stout et al, 2002; Duan et al, 2003; Bao et al, 2004; Suadicani et al, 2006; Kang et al, 2008; Liu et al, 2008; Iglesias et al, 2009; Bennett et al, 2012)
By using ATP-sniffer cells, Lalo et al recorded quantal ATP release in astrocytes freshly isolated from mouse cortex
Summary
Astrocytes are abundant in the central nervous system. They contact all types of cells in the brain, communicate with them, and modulate their activity by releasing gliotransmitters, including glutamate, ATP, etc. (Newman, 2003; Halassa and Haydon, 2010; Hamilton and Attwell, 2010; Volterra et al, 2014; Verkhratsky and Nedergaard, 2018), the role of astrocytes in neurotransmission is still debated (Nedergaard and Verkhratsky, 2012; Fiacco and McCarthy, 2018). It was our original goal to record quantal ATP release in cultured hippocampal astrocytes using ATP-sniffer cells.
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