Abstract
Organic Ca2+ antagonists are specific substances which interfere with the gating of Ca2+ channels. They are of great interest as they are effective drugs in the therapy of different heart diseases. At present one distinguishes between three main classes of Ca2+ antagonists: dihydropyridines (DHPs), phenylalkylamines (PAAs) and benzothiazepines (BTZs). These classes appear to have different binding sites at the Ca2+ channel which show a reciprocal allosteric interaction among each other and with additional Ca2+ binding sites (Glossmann et al., 1985).
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