Abstract
Publisher Summary This chapter discusses the pathways of signal transduction involving influx and mobilization of Ca2+ and generation of second messengers from hydrolysis of membrane phospholipids by phospholipases A2, C, and D. The schema of Ca2+- and lipid-mediated signaling in platelet activation consists of a complex network of interacting pathways of signal transduction. Elevation of cytosol free Ca2+ concentration, by stimulating the activity of multiple protein kinases, phospholipases, proteases, and other intracellular effector proteins, constitutes a pleiotropic activating signal in platelets as well as in other cell types. The multiplicity of protein kinase C (PKC) isoenzymes present in platelets, each with unique cofactor requirements and substrate specificity, suggests that individual isoenzymes may subserve discrete functions in the trafficking of intracellular signals that mediate platelet activation. Limited information exists at this time concerning the specific roles of individual isoenzymes of PKC in effecting cellular responses initiated by receptor-ligand interaction at the platelet surface. Ongoing investigation of Ca2+- and lipid-mediated signaling shall be required to elucidate the mechanisms of agonist-induced platelet activation in hemostasis and thrombosis.
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