Abstract
(1) Background: Cancer antigen 125 (CA125) is a glycoprotein that is expressed by tissue derived from coelomic epithelium in the pleura, peritoneum, pericardium. It has been shown that CA125 concentrations are correlated with NT-proBNP in older people with congestive heart failure (HF). We conducted a study on the association between concentrations of CA125 and NT-proBNP in a population-based cohort of older Polish women. (2) Methods: The current research is sub-study of a large, cross-sectional research project (PolSenior). The study group consisted of 1565 Caucasian women aged 65–102 years. To assess the relationship between CA125 and other variables a stepwise backward multivariate normal and skew-t regression analyses were performed. (3) Results: The median of CA125 concentration was 13.0 U/mL and values over the upper normal range limit (35 U/mL) were observed in 5.1% (n = 79) of the study cohort. The concentration of CA125 was positively related to age, hospitalization for HF and history of atrial fibrillation and chronic obstructive pulmonary disease, levels of NT-proBNP, IL-6, hs-CRP and triglycerides. We found in the multivariate analyses, that increased CA125 levels were independently associated with log10 (IL-6) (β = 11.022), history of hospitalization for HF (β = 4.619), log10 (NT-proBNP) (β = 4.416) and age (β = 3.93 for 10 years). (4) Conclusions: Despite the association between CA125 and NT-proBNP, the usefulness of CA125 for the detection of HF in older women is limited by factors such as inflammatory status and age.
Highlights
Cancer antigen 125 (CA125) is a glycoprotein that is expressed by tissue derived from coelomic epithelium and has a molecular weight estimated to range from 110 to more than 2000 kD [1].The CA125 serum level has been shown to be increased in women with ovarian cancer and less often in breast [2], lung [3] and gastrointestinal cancers [4]
We found in the multivariate analyses, that increased CA125 levels were independently associated with log10 (IL-6) (β = 11.022), history of hospitalization for heart failure (HF) (β = 4.619), log10 (NT-proBNP) (β = 4.416) and age (β = 3.93 for 10 years)
Several recent studies have shown that serum CA125 levels are elevated in heart failure (HF), atrial fibrillation (AF), and ischemic heart disease [6,7,8]
Summary
The CA125 serum level has been shown to be increased in women with ovarian cancer and less often in breast [2], lung [3] and gastrointestinal cancers [4] It is not a screening test for malignancies as it may be elevated in a variety of benign conditions (such as pregnancy, endometriosis, uterine leiomyomata, pelvic inflammatory disease, cirrhosis, peritonitis, pleuritis, pancreatitis, and tuberculosis) [5]. A few studies that have assessed the CA125 levels in selected groups of patients after cardiac surgery (cardiac transplantation, transcatheter aortic valve implantation) have been published so far [9,10]. It seems that neurohormonal and inflammatory activation, as well as increased central venous volume and congestion, are the factors that increase the level of CA125 [11,12]
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