Abstract
To know the function of the Ca 2+ channel containing α 12.3 (α 1E) subunit (Ca v2.3 channel) in spermatozoa, we analyzed Ca 2+ transients and sperm motility using a mouse strain lacking Ca v2.3 channel. The averaged rising rates of Ca 2+ transients induced by α- D-mannose–bovine serum albumin in the head region of Ca v2.3−/− sperm were significantly lower than those of Ca v2.3+/+ sperm. A computer-assisted sperm motility assay revealed that straight-line velocity and linearity were greater in Ca v2.3−/− sperm than those in Ca v2.3+/+ sperm. These results suggest that the Ca v2.3 channel plays some roles in Ca 2+ transients and the control of flagellar movement.
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