Ca 2+ and synaptic plasticity

Abstract

The induction and maintenance of synaptic plasticity is well established to be a Ca 2+-dependent process. The use of fluorescent imaging to monitor changes [Ca 2+] i in neurones has revealed a diverse array of signaling patterns across the different compartments of the cell. The Ca 2+ signals within these compartments are generated by voltage or ligand-gated Ca 2+ influx, and release from intracellular stores. The changes in [Ca 2+] i are directly linked to the activity of the neurone, thus a neurone's input and output is translated into a dynamic Ca 2+ code. Despite considerable progress in measuring this code much still remains to be determined in order to understand how the code is interpreted by the Ca 2+ sensors that underlie the induction of compartment-specific plastic changes.