Abstract
P-glycoprotein encoded by the ABCB1 gene constitutes a molecular barrier in the small and large bowel epithelium, and its different expression may influence susceptibility to inflammatory bowel disease (IBD). We aimed to assess the contribution of the C3435T polymorphism to disease risk in the Polish population. A total of 100 patients (50 Crohn’s disease (CD), 50 ulcerative colitis (UC)) and 100 healthy controls were genotyped for the single nucleotide polymorphism (SNP) C3435T by using the PCR-RFLP method. Patients were classified on the basis of disease phenotype and the specific treatment used. A meta-analysis was carried out of our results and those from previously published Polish studies. There was no significant difference in allele and genotype frequencies in IBD patients compared with controls. For CD patients, a lower frequency of TT genotype in those with colonic disease, a lower frequency of T allele, and a higher frequency of C allele in those with luminal disease were observed, whereas for UC patients, a lower frequency of CT genotype was observed in those with left-sided colitis. A meta-analysis showed a tendency towards higher prevalence of CC genotype in UC cases. These results indicate that the C3435T variants may confer a risk for UC and influence disease behaviour.
Highlights
Inflammatory bowel diseases (IBD) are heterogeneous disorders that cause chronic inflammation of the gastrointestinal tract with possible extraintestinal manifestations.Two main subtypes, i.e., Crohn’s disease (CD) and ulcerative colitis (UC), can be distinguished [1]
In UC it is confined to the colonic mucosa and epithelium [2,3]
IBD can occur in different geographic regions; in a systematic review of population-based studies the highest reported prevalence values were in Europe and North America (322 per 100,000 in Germany and 319 per 100,000 in Canada for CD and 505 per 100,000 in Norway and 286 per 100,000 in the US for UC, respectively) [4]
Summary
Inflammatory bowel diseases (IBD) are heterogeneous disorders that cause chronic inflammation of the gastrointestinal tract with possible extraintestinal manifestations. I.e., Crohn’s disease (CD) and ulcerative colitis (UC), can be distinguished [1]. They have many clinical presentations and pathological characteristics. The most typical for CD include diarrhoea, abdominal pain and systemic features like anorexia, malaise and fever. UC symptoms are most often bloody diarrhoea, colicky abdominal pain and tenesmus. The Western European countries, North America and Australia are characterized by a stable incidence and rapidly increasing prevalence due to the low mortality of IBD patients.
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