Abstract
Background: Gestational diabetes mellitus (GDM) is the most common metabolic disorder in pregnant women, defined as any degree of glucose intolerance with onset or first detected during pregnancy. Explanation of its pathogenesis is extremely important due to the possibility of preventing serious maternal and fetal complications. The aim of the study was to evaluate the concentrations of two molecules: C1q/tumor necrosis factor-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) which may possibly participate in GDM development. To our knowledge, this is the first study in pregnant women with GDM evaluating CTRP-3 level. Methods: Serum CTRP-3 and PEDF concentration and clinical characteristics were detected in 172 pregnant women. These women were divided into two groups: normal glucose tolerance group (NGT, n = 54) and gestational diabetes mellitus group (GDM, n = 118). This second group was further divided into two subgroups depending on the treatment used: GDM 1—diet only (n = 75) and GDM 2—insulin treatment (n = 43). Results: Our study did not reveal any statistically significant difference between the concentration of PEDF in the control and GDM group. In our study there was a significantly higher concentration of CTRP-3 evaluated in the peripheral blood serum in patients with gestational diabetes (GDM) compared to those in the control group (8.84 vs. 4.79 ng/mL). Significantly higher values of CTRP-3 were observed in both the diet-treated subgroup and the group with insulin therapy when compared to control group (8.40 and 10.96, respectively vs. 4.79 ng/mL). Conclusion: PEDF concentration does not change in GDM, whereas an increased level of CTRP-3 may point to the key role of this adipokine in the development of GDM.
Highlights
Gestational diabetes mellitus (GDM) is a special form of diabetes in pregnant women defined as any degree of glucose intolerance with onset or first recognition during pregnancy [1]
In the GDM group compared to the control group, median body mass index (BMI) was significantly higher (23.44 vs. 23.28; p = 0.0341)
A substantially higher concentration of CTRP3 in peripheral blood plasma was noted in the patients with diagnosed gestational diabetes mellitus (GDM) as compared to the respondents from the control group (8.84 vs. 4.79 ng/mL; p = 0.0265; Figure 2)
Summary
Gestational diabetes mellitus (GDM) is a special form of diabetes in pregnant women defined as any degree of glucose intolerance with onset or first recognition during pregnancy [1]. C1q/tumor necrosis factor-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF), may possibly participate in GDM development due to the fact that underlying mechanisms of GDM are, in general, similar to the mechanisms responsible for metabolic disorders such as type 2 diabetes mellitus or obesity. The aim of the study was to evaluate the concentrations of two molecules: C1q/tumor necrosis factor-related protein-3 (CTRP-3) and pigment epithelium-derived factor (PEDF) which may possibly participate in GDM development. Methods: Serum CTRP-3 and PEDF concentration and clinical characteristics were detected in 172 pregnant women These women were divided into two groups: normal glucose tolerance group (NGT, n = 54) and gestational diabetes mellitus group (GDM, n = 118). Conclusion: PEDF concentration does not change in GDM, whereas an increased level of CTRP-3 may point to the key role of this adipokine in the development of GDM
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